Fig. 5. (A) Oral administration of PP-p8 DDS led to a marked reduction in growth of DLD-1 tumors. Mice received 1 × 10¹⁰ cfu/head PP-EV DDS (five oral administrations/week), 1 × 10¹⁰ cfu/head PP-p8 DDS (five oral administrations/week), and/or 40 mg/kg 5-fluorouracil (intraperitoneal injection once/week). (B) Mean ± SEM tumor volume on day 28 post-treatment. (C) Mean ± SEM tumor weight on day 28 post-treatment. (D) Western blot showing effect of PP-p8 on expression of molecules associated with G₂ arrest in DLD-1 xenografts. EV, empty vector. A value of P < 0.05 was regarded as statistically significant. Mock vs 5-Fu: *, Mock vs PP-p8: † (*, † P < 0.05; **, †† P < 0.01; ***, ††† P < 0.001).

Mol. Cells 2019;42:755~762 https://doi.org/10.14348/molcells.2019.0064

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