Molecules and Cells

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Fig. 7.

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Fig. 7. (A) Huh-7 cells were cultured with (cocultured) or without IMR90 cells and pretreated with IOX-1 inhibitor for 24 h followed by IR exposure. The CXCL12 mRNA level of the unpretreated and unirradiated sample was arbitrarily set to one and compared to treated samples. (B and C) Expression of CD133+ CSC marker was also affected by inhibitors after treatment with IR. (D–F) Huh-7 cells were pretreated with IOX-1 inhibitor for 24 h before irradiation. (D) In 3 days, modifications of H3K4me3 and H3K9me3 at the human CXCL12 promoter were evaluated. (E) MMP2 and MMP9 mRNA were measured. *P < 0.05, **P < 0.01, ***P < 0.001. (F) Invasion was evaluated by incubating Huh7 cells in a Matrigel-coated chamber. Scale bar = 100 μm.
Mol. Cells 2019;42:530~545
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