Molecules and Cells

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Fig. 5.

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Fig. 5. (A) Invasion was evaluated by incubating Huh7 cells on a Matrigel-coated chamber at the indicated times after coculture or irradiation. (B and C) rCXCL12 treatment induced invasion of Huh7 cells. Scale bar = 100 μm. (D) Expression of MMP-2 and -9 in Huh7 cells was induced by radiation or coculture. MMP-2 and -9 mRNA were measured at indicated times. The levels of MMP-2 and -9 mRNAs in the single-cultured and unirradiated Huh7 cells were arbitrarily set to one. (E) rCXCL12 induced MMP-2 and -9 expression like irradiation. In contrast, AMD3100 blocked rCXCL12-induced MMP-2 and -9 expression. The MMP-2 and -9 mRNA levels at indicated times were measured after treatment with rCXCL12 with or without AMD3100. *P < 0.05, **P < 0.01.
Mol. Cells 2019;42:530~545
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