Molecules and Cells

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Fig. 4.

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Fig. 4. (A). The circular dichroism (CD) profiles of the wild type LysB4 (red), LysB4 R50Q (green), and LysB4 D129A (blue). (B). One water molecule coordinating Zn2+ is deprotonated by Asp129 residue (top). Then, the deprotonated water executes a nucleophilic attack on a carbonyl carbon of the peptide bond between L-alanine and D-glutamic acid in peptidoglycan stem peptide (top). In the next intermediate step, the Arg50 residue stabilizes the negatively charged tetrahedral intermediate (bottom).
Mol. Cells 2019;42:79~86
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