Molecules and Cells

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Fig. 5.

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Fig. 5. (A) EDCs can act via receptor-based mechanism, but at high doses, EDCs may employ receptor-independent mechanisms. EDCs (e.g., TCS) may also inhibit PMP-3-mediated detoxification mechanisms (). (B) EDCs could be inactivated in vivo by NIS-mediated micellar solubilization and the EDC-NIS complex may be exported at least in part by PMP-3/ABC transporters. (C) Upon micelle disruption, liberated EDC molecules regain their toxicity and may inhibit PMP-3-mediated detoxification.
Mol. Cells 2018;41:1052~1060
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