Molecules and Cells

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Fig. 5.

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Fig. 5. (A) NCI-H157 cells were transiently transfected with control siRNAs or Nrf2 siRNAs. Forty-eight hours after transfection, the cells were treated with PS-341 (50 nM) for 24 h. Total cellular extracts were subjected to Western blot analysis for PARP, Nrf2, and GAPDH. (B) Cells were infected with adenovirus vectors expressing WT-Nrf2 or DN-Nrf2. After 48 h, the cells were stimulated with PS-341 (50 nM) for 24 h. Cell viability was determined by MTT assay. Data represent the mean ± SD of triplicate experiments. **P < 0.05 (C) Schematic model depicting the development of resistance to PIs in lung cancer cells. Discussion includes further details. S.E., short exposure; L.E., long exposure
Mol. Cells 2018;41:1008~1015
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