Molecules and Cells

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Fig. 4.

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Fig. 4. Different serially-deleted zic3(40 pg/embryos) promoter constructs were co-injected with and without FoxD5b-En (280 pg/embryos) at the one-cell stage and grown until stage 11 to measure the relative promoter activity. (A) FoxD5b-En increased the relative promoter activity of zic3(−1805) promoter region compared to zic3(−1805) alone. (B) zic3(−517) and zic3(−517)mVRE1 promoter constructs were co-injected with and without FoxD5b-En in separate groups. The FoxD5b-mediated induction in the relative promoter activity of zic3(−517) was abolished in zic3(−517)mVRE1. (C) zic3(−517) and zic3(−517)mVRE1 promoter constructs were co-injected with and without Xcad2 in separate groups. The Xcad2-mediated reduction in the relative promoter activity of zic3(−517) was abolished in zic3(−517)mVRE1 reporter construct. The data are shown as mean ± S.E. of the values from at least three independent experiments. Differences were considered significant at P < 0.05.
Mol. Cells 2018;41:1061~1071 https://doi.org/10.14348/molcells.2018.0341
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