Molecules and Cells

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Fig. 3.

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Fig. 3. Lobe, Rosi, or Pio was treated to db/db mice for 4 weeks. (A) Crown-like structure was detected in EAT by hematoxylin and eosin (H&E) staining. Scale bars, 500 μm. (B) Macrophage accumulation in EAT was assessed by flow cytometric analysis. Total numbers of F4/80+CD11b+ and F4/80+CD11b+CD11c+ cells in SVCs per gram of EATs were determined. Relative mRNA levels of (C) macrophage markers, (D) pro-inflammatory cytokine and chemokine genes, and (E) anti-inflammatory genes were determined in EAT by RT-qPCR. All data represent the mean ± SEM (n = 3–5). *P < 0.05, **P < 0.01, ***P < 0.001 vs. vehicle group; $P < 0.05, $$P < 0.01 vs. Pio group by one-way ANOVA followed by Tukey’s post-hoc test. All RT-qPCR data were normalized to the mRNA level of cyclophilin.
Mol. Cells 2018;41:900~908
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