Molecules and Cells

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Fig. 2.

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Fig. 2. Upon energy stress-stimuli, the AMPK signaling pathway is upregulated, resulting in the increase of intracellular NAD+ level. At the same time, histone deacetylase SIRT1 and/or transcription factors such as PGC-1α are phosphorylated in AMPK-dependent manner. The enzymes involved in the pathways are in bold. P in green dots denotes for phosphorylation-mediated regulation. De-Ac in blue circles indicates deacetylation-mediated regulation. AMPK; AMP-activated kinase, NAMPT; nicotinamide phosphoribosyltransferase, SIRT1; sirtuin 1, PGC-1α; peroxisome proliferator-activated receptor gamma coactivator 1-alpha, AICAR; 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside.
Mol. Cells 2018;41:264~270
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