Molecules and Cells

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Fig. 1.

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Fig. 1. Growth factor-induced AKT signaling pathway upregulates acetyl-CoA production and phosphorylates histone modifying enzymes such as p300 and EZH2 to enhance histone acetylation on chromatin. The enzymes involved in the pathways are in bold. P in green dots denotes for phosphorylation-mediated regulation. Ac and Me refer to acetylation and methylation, respectively. GLUT1; glucose transporter 1, HK1; hexose kinase 1, PFK1/2; phosphofructokinase 1/2, RTKs; receptor tyrosine kinases, PI3K; phosphoinositide 3-kinae, ACL; ATP-citrate lyase, EZH2; enhancer of zeste homolog 2.
Mol. Cells 2018;41:264~270 https://doi.org/10.14348/molcells.2018.0076
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