Molecules and Cells

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Fig. 3.

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Fig. 3. The Main Drivers of Neurodegeneration in Alzheimer’s Disease.

Neuronal dysfunction and cell death are responsible for the development of Alzheimer’s disease. Accumulating evidence suggests that abnormally elevated tau hyperphosphorylation, pathogenic Aβ oligomers, and mitochondrial dysfunction cooperate to drive the neuronal dysfunction and cell death that underlie cognitive impairment. Although the amyloid hypothesis supports that neurotoxic Aβ primarily induces tau pathology, other proteolytic fragments of the human APP including sAPPβ, N-APP, and AICD, also appear to contribute to tau alterations. In addition, aging, which is tightly associated with mitochondrial dysfunction, can serve as the most significant nongenetic risk factor for Alzheimer’s disease.

Mol. Cells 2017;40:613~620
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