Molecules and Cells

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Fig. 2.

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Fig. 2. Human APP Mutations that Cause Familial Alzheimer’s Disease.

The amino acid sequence of the amyloid β-peptide (black box) and flanking transmembrane regions is presented; the horizontal arrows indicate the cleavage sites by α-, β-, andγ-secretases. Many missense and deletion mutations within the APP were discovered to cause an inherited form of Alzheimer’s disease.

Mol. Cells 2017;40:613~620
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