Molecules and Cells

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Fig. 2.

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Fig. 2. Potential integration of optogenetics and fNIRS.

Activity of neurons in a cortical (left panels) or a subcortical (right panels) region can be manipulated by expressing a light-responsive protein called an opsin (such as channelrhodopsin-2) and delivering photostimulation using a fiber-optic cable installed just above the target region (top panels) in the rodent brain. Using the same fiber-optic cable, a combination of wavelengths of near-infrared light can be delivered to the target brain region alternately (bottom panels). The neighboring fiber-optic cable, which is connected to the photodetector, captures the returning photons. Thus, it would be possible to perform targeted optogenetic manipulation and fNIRS imaging simultaneously in the same animal.

Mol. Cells 2017;40:523~532
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