Molecules and Cells

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Fig. 5.

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Fig. 5. Schematic diagram of a TALE nuclease (TALEN) dimer bound to target DNA.

TALE arrays are fused to the FokI nuclease domain to make a custom nuclease that can recognize unique left and right half-sites. The two TALE binding sites are separated by a spacer of 12–20 bp in length.

Mol. Cells 2017;40:533~541
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