Molecules and Cells

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Fig. 1.

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Fig. 1. DNA bound structure of a zinc finger protein (ZFP).

ZFP Aart (PDB ID: 2I13) is flanking the major groove of DNA, making contact with the edge of the nucleotide bases. Aart is a designed six finger protein with pentapeptide linkers, which recognizes an A-rich 18 bp sequence (Segal et al., 2006). The DNA is slightly unwound in order to allow 11.3 bp/turn.

Mol. Cells 2017;40:533~541
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