Molecules and Cells

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Fig. 3.

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Fig. 3. The accumulation of misfolded proteins and their aggregates stimulates the cytosolic relocalization and N-terminal arginylation of ER-residing chaperones such as BiP, calreticulin, and protein disulfide isomerase. Cytosolic R-BiP is associated with cargoes and bind the ZZ domain of p62, facilitating p62 self-polymerization and interaction with LC3. In addition, the ligand-bound p62 induces autophagosome biogenesis. Through this dual regulation, cells can efficiently remove misfolded proteins in a real time basis.
Mol. Cells 2017;40:441~449 https://doi.org/10.14348/molcells.2017.0115
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