Molecules and Cells

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Fig. 3.

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Fig. 3. Sep15 knockdown induces the expression of ER stress response markers. (A) Relative levels of GRP78 mRNA in shSep15+Dox versus -Dox cells were measured. Treatment times and cell lines are indicated on the bottom of the graph. (B) Relative levels of CHOP mRNA. (C) Alternative splicing of XBP1 mRNA was induced by Sep15-deficiency. The 424 bp, 450 bp, and 398 bp XBP1 bands represent the unspliced, hybrid, and spliced forms, respectively. As a control, cells were treated with tunicamycin (TM) or dithiothreitol (DTT). ** indicates significance at p < 0.001.
Mol. Cells 2015;38:457~465
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